SKINTEGRITY.CH Principal Investigators are in bold


Fenini, G., Karakaya, T., Hennig, P., Di Filippo, M., Slaufova, M., & Beer, H. D. (2022). NLRP1 Inflammasome Activation in Keratinocytes: Increasing Evidence of Important Roles in Inflammatory Skin Diseases and Immunity. J Invest Dermatol, in press.

Guendisch, U., Loos, B., Cheng, P. F., Dummer, R., Levesque, M. P., Varum, S., & Sommer, L. (2022). Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation. Front Cell Dev Biol, 10(916033), 1152.

He,Y., Tacconi, C., Dieterich, L.C., Kim, J., Restivo, G., Gousopoulos, E., Lindenblatt, N., Levesque, M.P., Claassen, M., & Detmar, M. (2022). Novel blood vascular endothelial subtype-specific markers in human skin unearthed by single-cell transcriptomic profiling. Cells, 11(7), 1111.

Krzywinska, E., Sobecki, M., Nagarajan, S., Zacharjasz, J., Tambuwala, M. M., Pelletier, A., Cummins, E., Gotthardt, D., Fandrey, J., Kerdiles, Y.M., Peyssonnaux, C., Taylor, C.T., Sexl, V., & Stockmann, C. (2022). The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. J Exp Med, 219(2), e20210909.

Liu, Y.H., Brunner, L.M., Rebling, J., Ben-Yehuda Greenwald, M., Werner, S., Detmar, M., & Razansky, D. (2022). Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds. Theranostics, 12(2), 558-573.

Luo XG, Kuipers J & Beerenwinkel N (2022). Joint inference of repeated evolutionary trajectories and patterns of clonal exclusivity or co-occurrence from tumor mutation trees. Preprint,

Martínez-Martínez, E., Atzei, P., Vionnet, C., Roubaty, C., Kaeser-Pebernard, S., Naef, R., & Dengjel, J. (2022). A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts. Int J Mol Sci, 23(12), 6860.

Pontiggia, L., Van Hengel, I. A., Klar, A., Rütsche, D., Nanni, M., Scheidegger, A., Figi, S., Reichmann, E., Moehrlen, U., & Biedermann, T. (2022). Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform. J Tissue Eng, 13(20417314221088513).

Sanchez-Macedo, N., McLuckie M., Grünherz, L., & Lindenblatt, N. (2022). Protein profiling of mechanically processed lipoaspirates: discovering wound healing and anti-fibrotic biomarkers in nanofat. Plast Reconstr Surg, 10.1097(9345).

Yan, S., Ripamonti, R., Kawabe, H., Ben-Yehuda Greenwald, M. B. Y., & Werner, S. (2022). NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair. J Invest Dermatol, 142(6), 1703-1713.


Aronoff, M. R., Hiebert, P., Hentzen, N. B., Werner, S., & Wennemers, H. (2021). Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide. Nat Chem Biol, 17, 865-871.

Bernasconi, R., Thriene, K., RomeroFernández, E., Gretzmeier, C., Kühl, T., Maler, M., Nauroy, P., Kleiser, S., Rühl-Muth, A.-C., Stumpe, M., Kiritsi, D., Martin, S.F., Hinz, B., Bruckner-Tuderman, L., Dengjel, J. & Nyström, A. (2021). Proinflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang(17). EMBO Mol Med, e14392.

De Pieri, A., Korman, B. D., Jüngel, A., & WuertzKozak, K. (2021). Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development. Adv Biology, 5(4), 2000168.

Dudaryeva, O.Y., Bucciarelli, A., Bovone, G., Huwyler, F., Jaydev, S., Broguiere, N., al Bayati, M., Lütolf, M., and Tibbitt, M.W. 3D confinement regulates cell life and death. Adv Funct Mater, 31, 2104098.

Hennig, P., Fenini, G., Di Filippo, M., Karakaya, T., & Beer, H.-D. (2021). The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer. Biomedicines, 9(7), 707.

Hu, Z., Sankar, D.S., Vu, B., Leytens, A., Vionnet, C., Wu, W., Stumpe, M., Martínez-Martínez, E., Stork, B. & Dengjel, J. (2021). ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy. Cell Rep, 36(13), 109762.

Martínez-Martínez, E., Tölle, R., Donauer, J., Gretzmeier, C., Bruckner-Tuderman, L. & Dengjel, J. (2021). Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa. Matrix Biol, 1698.

Meier-Schiesser, B., Mellett, M., Ramirez-Fort, M. K., Maul, J.-T., Klug, A., Winkelbeiner, N., Fenini, G., Schafer, P., Contassot, E. & French, L.E. (2021). Phosphodiesterase-4 inhibition reduces cutaneous inflammation and IL-1β expression in a psoriasiform mouse model but does not inhibit inflammasome activation. Int J Mol Sci, 22(23):12878.

Mitamura, Y., Schulz, D., Oro, S., Li, N., Kolm, I., Lang, C.V., Ziadlou, R., Tan, G., Bodenmiller, B., Steiger, P., Marzano, A., Prost, N. de, Caudin, O., Levesque, M., Stoffel, C., Schmid-Grendelmeier, P., Maverakis, E., Akdis, C.A. and Brüggen MC (2021). Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients. Allergy, 2021;00:1-14.

Müller, B., Mazza, E., Schiestl, C., & Elrod, J. (2021). Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients. Burns & trauma, 9, tkab028.

Polomska, A., Gousopoulos, E., Fehr, D., Bachmann, A., Bonmarin, M., Detmar, M. & Lindenblatt, N. (2021). Development and Clinical Validation of the LymphMonitor Technology to Quantitatively Assess Lymphatic Function. Diagnostics, 11(1873), 1-14.

Ramelyte, E., Tastanova, A., Balázs, Z., Ignatova, D., Turko, P., Menzel, U., Guenova, E., Beisel, C., Krauthammer, M., Levesque, M. P., & Dummer, R. (2021). Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective. Cancer Cell, 39(3), 394-406.

Rebling, J., Ben-Yehuda Greenwald, M., Wietecha, M., Werner, S., & Razansky, D. (2021). LongTerm Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy. Adv Sci, 2004226.

Sachs, D., Wahlsten, A., Kozerke, S., Restivo, G., & Mazza, E. (2021). A biphasic multilayer computational model of human skin. Biomech Model Mechan, 20(3), 969-982.

Sobecki, M., Krzywinska, E., Nagarajan, S., Audigé, A., Huỳnh, K., Zacharjasz, J., Debbache, J., Kerdiles, Y., Gotthardt, D., Takeda, N., Fandrey, J., Sommer, L., Sexl, V., & Stockmann, C. (2021). NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence. Nat Com, 12(1), 1-15.

Tastanova, A., Ramelyte, E., Balázs, Z., Menzel, U., Beisel, C., Krauthammer, M., Dummer, R., & Levesque, M. P. (2021). Collection and preprocessing of fine needle aspirate patient samples for single cell profiling and data analysis. STAR protocols, 2(2), 100581.

Vu, B., Souza, G. R., & Dengjel, J. (2021). Scaffold-free 3D cell culture of primary skin fibroblasts induces profound changes of the matrisome. Matrix Biol Plus, 100066.

Wahlsten, A., Rütsche, D., Nanni, M., Giampietro, C., Biedermann, T., Reichmann, E., & Mazza, E. (2021). Mechanical stimulation induces rapid fibroblast proliferation and accelerates the early maturation of human skin substitutes. Biomaterials, 273, 120779.

Zwicky, P., Ingelfinger, F., Silva de Melo, B. M., Ruchti, F., Schärli, S., Puertas, N., Lutz, M., Phan, T.S., Kündig, T.M., Levesque, M.P., Maul, J.-T., Schlapbach, C., Leibundgut-Landmann, S., Mundt, S. & Becher, B. (2021). IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Sci Immunol, 6(64), eabg9012.


Babity, S., Polomska, A. K., Couture, F., Bonmarin, M., Fehr, D., Detmar, M., & Brambilla, D. (2020). Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function. J Control Release, 327, 350-359.

Bircher, K., Merluzzi, R., Wahlsten, A., Spiess, D., Simoes-Wust, A. P., Ochsenbein-Kolble, N., Deprest, R., & Mazza, E. (2020). Influence of osmolarity and hydration on the tear resistance of the human amniotic membrane. J Biomech, 98, 109419.

Cangkrama, M., Wietecha, M., Mathis, N., Okumura, R., Ferrarese, L., Al-Nuaimi, D., Antsiferova, M., Dummer, R., Innocenti, M., & Werner, S. (2020). A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming. EMBO Mol Med, 12(4), e11466.

Hennig, P., Fenini, G., Di Filippo, M., & Beer, H.-D. (2020). Electrophiles Against (Skin) Diseases: More Than Nrf2. Biomolecules, 10(2).

Hettich, B. F., Ben-Yehuda Greenwald, M., Werner, S., & Leroux, J.-C. (2020). Exosomes for Wound Healing: Purification Optimization and Identification of Bioactive Components. Adv Sci, 7(23), 2002596.

Lautenbach, G., Dobrota, R., Mihai, C., Distler, O., Calcagni, M., & Maurer, B. (2020). Evaluation of botulinum toxin A injections for the treatment of refractory chronic digital ulcers in patients with systemic sclerosis. Clin Exp Rheumatol, 38 Suppl 125(3), 154-160.

McLuckie, M., Robotti, F., Sanchez-Macedo, N., Enderlin, D., Frese, L., Cheng, P. F., Levesque, M. P., Egaña, J. T., Poulikakos, D., Ferrari, A., & Lindenblatt, N. (2020). Lipoconstruct surface topography grating size influences vascularization onset in the dorsal skinfold chamber model. Acta Biomater, 106, 136-144.

Moser, T., Lohmeyer, Q., Meboldt, M., Distler, O., & Becker, M. O. (2020). Visual assessment of digital ulcers in systemic sclerosis analysed by eye tracking: implications for wound assessment. Clin Exp Rheumatol, 38 Suppl 125(3), 137-139.

Mueller, B., Elrod, J., Distler, O., Schiestl, C., & Mazza, E. (2020). On the Reliability of Suction Measurements for Skin Characterization. J Biomech Eng.

Mueller, B., Ruby, L., Jordan, S., Rominger, M. B., Mazza, E., & Distler, O. (2020). Validation of the suction device Nimble for the assessment of skin fibrosis in systemic sclerosis. Arthritis Res Ther, 22(1), 128.

Pachera, E., Assassi, S., Salazar, G. A., Stellato, M., Renoux, F., Wunderlin, A., Blyszczuk, P., Lafyatis, R., Kurreeman, F., De Vries-Bouwstra, J., Messemaker, T., Feghali-Bostwick, C. A., Rogler, G., Van Haaften, W. T., Dijkstra, G., Oakley, F., Calcagni, M., Schniering, J., Maurer, B., Distler, J. H. W., Kania, G., Frank-Bertoncelj, M., & Distler, O. (2020). Long noncoding RNA H19X is a key mediator of TGF-beta-driven fibrosis. J Clin Invest, 130(9), 4888-4905.

Renoux, F., Stellato, M., Haftmann, C., Vogetseder, A., Huang, R., Subramaniam, A., Becker, M. O., Blyszczuk, P., Becher, B., Distler, J. H. W., Kania, G., Boyman, O., & Distler, O. (2020). The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development. Cell Rep, 31(13), 107826.

Satoh, T. K., Mellett, M., Meier-Schiesser, B., Fenini, G., Otsuka, A., Beer, H.-D., Rordorf, T., Maul, J.-T., Hafner, J., Navarini, A. A., Contassot, E., & French, L. E. (2020). IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. J Clin Invest.

Wietecha, M. S., Pensalfini, M., Cangkrama, M., Mueller, B., Jin, J., Brinckmann, J., Mazza, E., & Werner, S. (2020). Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Nat Commun, 11(1), 2604.


Elrod, J., Mueller, B., Mohr, C., Meuli, M., Mazza, E., & Schiestl, C. (2019). An effective procedure for skin stiffness measurement to improve Paediatric Burn Care. Burns, 45(5), 1102-1111.

Fox, S. C., Biedermann, T., Polak, J., Reichmann, E., Daners, M. S., & Meboldt, M. (2019). A simplified fabrication technique for cellularized high-collagen dermal equivalents. Biomed Mater, 14(4), 041001.

Fox, S. C., Polak, J., Schmid Daners, M., & Meboldt, M. (2019). Fabrication of Bioengineered Skin by Injection Molding: A Feasibility Study on Automation. SLAS Technol, 24(5), 506-514.

Fox, S. C., Siallagan, D., Schmid Daners, M., & Meboldt, M. (2019). Rethinking automated skin fabrication for regeneration: adapting to commercial challenges. Current Opinion in Biomedical Engineering, 10, 165-173.

Matei, A. E., Chen, C. W., Kiesewetter, L., Gyorfi, A. H., Li, Y. N., Trinh-Minh, T., Xu, X., Tran Manh, C., van Kuppevelt, T., Hansmann, J., Jüngel, A., Schett, G., Groeber-Becker, F., & Distler, J. H. W. (2019). Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Ann Rheum Dis, 78(12), 1686-1692.

Michalak-Micka, K., Klar, A. S., Bottcher-Haberzeth, S., Reichmann, E., Meuli, M., & Biedermann, T. (2019). Impact of human mesenchymal cells of different body site origins on the maturation of dermo-epidermal skin substitutes. Pediatr Surg Int, 35(1), 121-127.

Morel, A., Oberle, S. C., Ulrich, S., Yazgan, G., Spano, F., Ferguson, S. J., Fortunato, G., & Rossi, R. M. (2019). Revealing non-crystalline polymer superstructures within electrospun fibers through solvent-induced phase rearrangements. Nanoscale, 11(36), 16788-16800.

Polomska, A. K., Proulx, S. T., Brambilla, D., Fehr, D., Bonmarin, M., Brandli, S., Meboldt, M., Steuer, C, Vasileva T., Reinke, N., Leroux, J.-C., & Detmar, M. (2019). Minimally invasive method for the point-of-care quantification of lymphatic vessel function. JCI Insight, 4(4).

Tuncer, E., Calçada, R. C., Zingg, D., Varum, S., Cheng, P., Freiberger, S. N., Deng, C.-X., Kleiter, I., Levesque, M. P., Dummer, R., & Sommer, L. (2019). SMAD signaling promotes melanoma metastasis independently of phenotype switching. J. Clin. Invest., 129:2702-2716.

Varum, S., Baggiolini, A., Zurkirchen, L., Kalender Atak, Z., Cantù, C., Marzorati, E., Bossart, R., Wouters, J., Häusel, J., Tuncer, E., Zingg, D., Veen, D., John, N., Balz, M., Levesque, M. P., Basler, K., Aerts, S., Zamboni, N., Dummer, R. & Sommer, L. (2019). Yin Yang 1 orchestrates a metabolic program required for both neural crest development and melanoma formation. Cell Stem Cell, 24:637-653.

Wahlsten, A., Pensalfini, M., Stracuzzi, A., Restivo, G., Hopf, R., & Mazza, E. (2019). On the compressibility and poroelasticity of human and murine skin. Biomech Model Mechanobiol, 18(4), 1079-1093.


Mueller, B., Elrod, J., Pensalfini, M., Hopf, R., Distler, O., Schiestl, C., & Mazza, E. (2018). A novel ultra-light suction device for mechanical characterization of skin. PLoS One, 13(8), e0201440.

Parfejevs, V., Debbache, J., Shakhova, O., Schaefer, S. M., Glausch, M., Wegner, M., Suter, U., Riekstina, U., Werner, S., & Sommer, L. (2018). Injury-activated glial cells promote wound healing of the adult skin in mice. Nature Communications, 9, 236.

Pensalfini, M., Meneghello, S., Lintas, V., Bircher, K., Ehret, A. E., & Mazza, E. (2018). The suture retention test, revisited and revised. Journal of the Mechanical Behavior of Biomedical Materials, 77, 711-717.

Pensalfini, M., Weickenmeier, J., Rominger, M., Santoprete, R., Distler, O., & Mazza, E. (2018). Location-specific mechanical response and morphology of facial soft tissues. Journal of the Mechanical Behavior of Biomedical Materials, 78, 108-115.

Randall, M. J., Jungel, A., Rimann, M., & Wuertz-Kozak, K. (2018). Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models. Front Bioeng Biotechnol, 6, 154.

Zimmerli, D., Cecconi, V., Valenta, T., Hausmann, G., Cantu, C., Restivo, G., Hafner, J., Basler, K., & Van den Broek, M. (2018). WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma. Oncogene, 37(27), 3753-3762.

Zingg D, Debbache J, Peña-Hernández R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calçada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L (2018). EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell 34: 69-84.


Klar, A. S., Biedermann, T., Michalak, K., Michalczyk, T., Meuli-Simmen, C., Scherberich, A., Meuli, M., & Reichmann, E. (2017). Human Adipose Mesenchymal Cells Inhibit Melanocyte Differentiation and the Pigmentation of Human Skin via Increased Expression of TGF-beta1. J Invest Dermatol, 137(12), 2560-2569.

Pensalfini, M., Ehret, A. E., Stüdeli, S., Marino, D., Kaech, A., Reichmann, E., & Mazza, E. (2017). Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering. J Mech Behav Biomed, 69, 85-97.

Pensalfini, M., Haertel, E., Hopf, R., Wietecha, M., Werner, S., & Mazza, E. (2017). The mechanical fingerprint of murine excisional wounds. Acta Biomater, 1-11.