SKINTEGRITY.CH Principal Investigators are in bold
2022
Fenini, G., Karakaya, T., Hennig, P., Di Filippo, M., Slaufova, M., & Beer, H. D. (2022). NLRP1 Inflammasome Activation in Keratinocytes: Increasing Evidence of Important Roles in Inflammatory Skin Diseases and Immunity. J Invest Dermatol, in press. https://doi.org/10.1016/j.jid.2022.04.004
Guendisch, U., Loos, B., Cheng, P. F., Dummer, R., Levesque, M. P., Varum, S., & Sommer, L. (2022). Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation. Front Cell Dev Biol, 10(916033), 1152. https://doi.org/10.3389/fcell.2022.916033
He,Y., Tacconi, C., Dieterich, L.C., Kim, J., Restivo, G., Gousopoulos, E., Lindenblatt, N., Levesque, M.P., Claassen, M., & Detmar, M. (2022). Novel blood vascular endothelial subtype-specific markers in human skin unearthed by single-cell transcriptomic profiling. Cells, 11(7), 1111. https://doi.org/10.3390/cells11071111
Krzywinska, E., Sobecki, M., Nagarajan, S., Zacharjasz, J., Tambuwala, M. M., Pelletier, A., Cummins, E., Gotthardt, D., Fandrey, J., Kerdiles, Y.M., Peyssonnaux, C., Taylor, C.T., Sexl, V., & Stockmann, C. (2022). The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. J Exp Med, 219(2), e20210909. https://doi.org/10.1084/jem.20210909
Liu, Y.H., Brunner, L.M., Rebling, J., Ben-Yehuda Greenwald, M., Werner, S., Detmar, M., & Razansky, D. (2022). Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds. Theranostics, 12(2), 558-573. https://doi.org/10.7150/thno.65287
Luo XG, Kuipers J & Beerenwinkel N (2022). Joint inference of repeated evolutionary trajectories and patterns of clonal exclusivity or co-occurrence from tumor mutation trees. Preprint, https://doi.org/10.1101/2021.11.04.467347
Martínez-Martínez, E., Atzei, P., Vionnet, C., Roubaty, C., Kaeser-Pebernard, S., Naef, R., & Dengjel, J. (2022). A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Activates Autophagy in Primary Skin Fibroblasts. Int J Mol Sci, 23(12), 6860. https://doi.org/10.3390/ijms23126860
Pontiggia, L., Van Hengel, I. A., Klar, A., Rütsche, D., Nanni, M., Scheidegger, A., Figi, S., Reichmann, E., Moehrlen, U., & Biedermann, T. (2022). Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform. J Tissue Eng, 13(20417314221088513). https://doi.org/10.1177/20417314221088513
Sanchez-Macedo, N., McLuckie M., Grünherz, L., & Lindenblatt, N. (2022). Protein profiling of mechanically processed lipoaspirates: discovering wound healing and anti-fibrotic biomarkers in nanofat. Plast Reconstr Surg, 10.1097(9345). https://doi.org/10.1097/prs.0000000000009345
Yan, S., Ripamonti, R., Kawabe, H., Ben-Yehuda Greenwald, M. B. Y., & Werner, S. (2022). NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair. J Invest Dermatol, 142(6), 1703-1713. https://doi.org/10.1016/j.jid.2021.09.033
2021
Aronoff, M. R., Hiebert, P., Hentzen, N. B., Werner, S., & Wennemers, H. (2021). Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide. Nat Chem Biol, 17, 865-871. https://doi.org/10.1038/s41589-021-00830-6
Bernasconi, R., Thriene, K., Romero‐Fernández, E., Gretzmeier, C., Kühl, T., Maler, M., Nauroy, P., Kleiser, S., Rühl-Muth, A.-C., Stumpe, M., Kiritsi, D., Martin, S.F., Hinz, B., Bruckner-Tuderman, L., Dengjel, J. & Nyström, A. (2021). Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7). EMBO Mol Med, e14392. https://doi.org/10.15252/emmm.202114392
De Pieri, A., Korman, B. D., Jüngel, A., & Wuertz‐Kozak, K. (2021). Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development. Adv Biology, 5(4), 2000168. https://doi.org/10.1002/adbi.202000168
Dudaryeva, O.Y., Bucciarelli, A., Bovone, G., Huwyler, F., Jaydev, S., Broguiere, N., al Bayati, M., Lütolf, M., and Tibbitt, M.W. 3D confinement regulates cell life and death. Adv Funct Mater, 31, 2104098. https://doi.org/10.1002/adfm.2021040
Hennig, P., Fenini, G., Di Filippo, M., Karakaya, T., & Beer, H.-D. (2021). The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer. Biomedicines, 9(7), 707. https://doi.org/10.3390/biomedicines9070707
Hu, Z., Sankar, D.S., Vu, B., Leytens, A., Vionnet, C., Wu, W., Stumpe, M., Martínez-Martínez, E., Stork, B. & Dengjel, J. (2021). ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy. Cell Rep, 36(13), 109762. https://doi.org/10.1016/j.celrep.2021.109762
Martínez-Martínez, E., Tölle, R., Donauer, J., Gretzmeier, C., Bruckner-Tuderman, L. & Dengjel, J. (2021). Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa. Matrix Biol, 1698. https://doi.org/10.1016/j.matbio.2021.10.004
Meier-Schiesser, B., Mellett, M., Ramirez-Fort, M. K., Maul, J.-T., Klug, A., Winkelbeiner, N., Fenini, G., Schafer, P., Contassot, E. & French, L.E. (2021). Phosphodiesterase-4 inhibition reduces cutaneous inflammation and IL-1β expression in a psoriasiform mouse model but does not inhibit inflammasome activation. Int J Mol Sci, 22(23):12878. https://doi.org/10.3390/ijms222312878
Mitamura, Y., Schulz, D., Oro, S., Li, N., Kolm, I., Lang, C.V., Ziadlou, R., Tan, G., Bodenmiller, B., Steiger, P., Marzano, A., Prost, N. de, Caudin, O., Levesque, M., Stoffel, C., Schmid-Grendelmeier, P., Maverakis, E., Akdis, C.A. and Brüggen MC (2021). Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients. Allergy, 2021;00:1-14. https://doi.org/10.1111/all.14983
Müller, B., Mazza, E., Schiestl, C., & Elrod, J. (2021). Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients. Burns & trauma, 9, tkab028. https://doi.org/10.1093/burnst/tkab028
Polomska, A., Gousopoulos, E., Fehr, D., Bachmann, A., Bonmarin, M., Detmar, M. & Lindenblatt, N. (2021). Development and Clinical Validation of the LymphMonitor Technology to Quantitatively Assess Lymphatic Function. Diagnostics, 11(1873), 1-14. https://doi.org/10.3390/diagnostics11101873
Ramelyte, E., Tastanova, A., Balázs, Z., Ignatova, D., Turko, P., Menzel, U., Guenova, E., Beisel, C., Krauthammer, M., Levesque, M. P., & Dummer, R. (2021). Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective. Cancer Cell, 39(3), 394-406. https://doi.org/10.1016/j.ccell.2020.12.022
Rebling, J., Ben-Yehuda Greenwald, M., Wietecha, M., Werner, S., & Razansky, D. (2021). Long‐Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy. Adv Sci, 2004226. https://doi.org/10.1002/advs.202004226
Sachs, D., Wahlsten, A., Kozerke, S., Restivo, G., & Mazza, E. (2021). A biphasic multilayer computational model of human skin. Biomech Model Mechan, 20(3), 969-982. https://doi.org/10.1007/s10237-021-01424-w
Sobecki, M., Krzywinska, E., Nagarajan, S., Audigé, A., Huỳnh, K., Zacharjasz, J., Debbache, J., Kerdiles, Y., Gotthardt, D., Takeda, N., Fandrey, J., Sommer, L., Sexl, V., & Stockmann, C. (2021). NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence. Nat Com, 12(1), 1-15. https://doi.org/10.1038/s41467-021-25065-w
Tastanova, A., Ramelyte, E., Balázs, Z., Menzel, U., Beisel, C., Krauthammer, M., Dummer, R., & Levesque, M. P. (2021). Collection and preprocessing of fine needle aspirate patient samples for single cell profiling and data analysis. STAR protocols, 2(2), 100581. https://doi.org/10.1016/j.xpro.2021.100581
Vu, B., Souza, G. R., & Dengjel, J. (2021). Scaffold-free 3D cell culture of primary skin fibroblasts induces profound changes of the matrisome. Matrix Biol Plus, 100066. https://doi.org/10.1016/j.mbplus.2021.100066
Wahlsten, A., Rütsche, D., Nanni, M., Giampietro, C., Biedermann, T., Reichmann, E., & Mazza, E. (2021). Mechanical stimulation induces rapid fibroblast proliferation and accelerates the early maturation of human skin substitutes. Biomaterials, 273, 120779. https://doi.org/10.1016/j.biomaterials.2021.120779
Zwicky, P., Ingelfinger, F., Silva de Melo, B. M., Ruchti, F., Schärli, S., Puertas, N., Lutz, M., Phan, T.S., Kündig, T.M., Levesque, M.P., Maul, J.-T., Schlapbach, C., Leibundgut-Landmann, S., Mundt, S. & Becher, B. (2021). IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Sci Immunol, 6(64), eabg9012. https://doi.org/10.1126/sciimmunol.abg9012
2020
Babity, S., Polomska, A. K., Couture, F., Bonmarin, M., Fehr, D., Detmar, M., & Brambilla, D. (2020). Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function. J Control Release, 327, 350-359. https://doi.org/10.1016/j.jconrel.2020.08.017
Bircher, K., Merluzzi, R., Wahlsten, A., Spiess, D., Simoes-Wust, A. P., Ochsenbein-Kolble, N., Deprest, R., & Mazza, E. (2020). Influence of osmolarity and hydration on the tear resistance of the human amniotic membrane. J Biomech, 98, 109419. https://doi.org/10.1016/j.jbiomech.2019.109419
Cangkrama, M., Wietecha, M., Mathis, N., Okumura, R., Ferrarese, L., Al-Nuaimi, D., Antsiferova, M., Dummer, R., Innocenti, M., & Werner, S. (2020). A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming. EMBO Mol Med, 12(4), e11466. https://doi.org/10.15252/emmm.201911466
Hennig, P., Fenini, G., Di Filippo, M., & Beer, H.-D. (2020). Electrophiles Against (Skin) Diseases: More Than Nrf2. Biomolecules, 10(2). https://doi.org/10.3390/biom10020271
Hettich, B. F., Ben-Yehuda Greenwald, M., Werner, S., & Leroux, J.-C. (2020). Exosomes for Wound Healing: Purification Optimization and Identification of Bioactive Components. Adv Sci, 7(23), 2002596. https://doi.org/10.1002/advs.202002596
Lautenbach, G., Dobrota, R., Mihai, C., Distler, O., Calcagni, M., & Maurer, B. (2020). Evaluation of botulinum toxin A injections for the treatment of refractory chronic digital ulcers in patients with systemic sclerosis. Clin Exp Rheumatol, 38 Suppl 125(3), 154-160.
McLuckie, M., Robotti, F., Sanchez-Macedo, N., Enderlin, D., Frese, L., Cheng, P. F., Levesque, M. P., Egaña, J. T., Poulikakos, D., Ferrari, A., & Lindenblatt, N. (2020). Lipoconstruct surface topography grating size influences vascularization onset in the dorsal skinfold chamber model. Acta Biomater, 106, 136-144. https://doi.org/10.1016/j.actbio.2020.01.050
Moser, T., Lohmeyer, Q., Meboldt, M., Distler, O., & Becker, M. O. (2020). Visual assessment of digital ulcers in systemic sclerosis analysed by eye tracking: implications for wound assessment. Clin Exp Rheumatol, 38 Suppl 125(3), 137-139. https://www.clinexprheumatol.org/article.asp?a=15763
Mueller, B., Elrod, J., Distler, O., Schiestl, C., & Mazza, E. (2020). On the Reliability of Suction Measurements for Skin Characterization. J Biomech Eng. https://doi.org/10.1115/1.4047661
Mueller, B., Ruby, L., Jordan, S., Rominger, M. B., Mazza, E., & Distler, O. (2020). Validation of the suction device Nimble for the assessment of skin fibrosis in systemic sclerosis. Arthritis Res Ther, 22(1), 128. https://doi.org/10.1186/s13075-020-02214-y
Pachera, E., Assassi, S., Salazar, G. A., Stellato, M., Renoux, F., Wunderlin, A., Blyszczuk, P., Lafyatis, R., Kurreeman, F., De Vries-Bouwstra, J., Messemaker, T., Feghali-Bostwick, C. A., Rogler, G., Van Haaften, W. T., Dijkstra, G., Oakley, F., Calcagni, M., Schniering, J., Maurer, B., Distler, J. H. W., Kania, G., Frank-Bertoncelj, M., & Distler, O. (2020). Long noncoding RNA H19X is a key mediator of TGF-beta-driven fibrosis. J Clin Invest, 130(9), 4888-4905. https://doi.org/10.1172/JCI135439
Renoux, F., Stellato, M., Haftmann, C., Vogetseder, A., Huang, R., Subramaniam, A., Becker, M. O., Blyszczuk, P., Becher, B., Distler, J. H. W., Kania, G., Boyman, O., & Distler, O. (2020). The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development. Cell Rep, 31(13), 107826. https://doi.org/10.1016/j.celrep.2020.107826
Satoh, T. K., Mellett, M., Meier-Schiesser, B., Fenini, G., Otsuka, A., Beer, H.-D., Rordorf, T., Maul, J.-T., Hafner, J., Navarini, A. A., Contassot, E., & French, L. E. (2020). IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. J Clin Invest. https://doi.org/10.1172/JCI128678
Wietecha, M. S., Pensalfini, M., Cangkrama, M., Mueller, B., Jin, J., Brinckmann, J., Mazza, E., & Werner, S. (2020). Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Nat Commun, 11(1), 2604. https://doi.org/10.1038/s41467-020-16409-z
2019
Elrod, J., Mueller, B., Mohr, C., Meuli, M., Mazza, E., & Schiestl, C. (2019). An effective procedure for skin stiffness measurement to improve Paediatric Burn Care. Burns, 45(5), 1102-1111. https://doi.org/10.1016/j.burns.2019.02.004
Fox, S. C., Biedermann, T., Polak, J., Reichmann, E., Daners, M. S., & Meboldt, M. (2019). A simplified fabrication technique for cellularized high-collagen dermal equivalents. Biomed Mater, 14(4), 041001. https://doi.org/10.1088/1748-605X/ab09c5
Fox, S. C., Polak, J., Schmid Daners, M., & Meboldt, M. (2019). Fabrication of Bioengineered Skin by Injection Molding: A Feasibility Study on Automation. SLAS Technol, 24(5), 506-514. https://doi.org/10.1177/2472630319857966
Fox, S. C., Siallagan, D., Schmid Daners, M., & Meboldt, M. (2019). Rethinking automated skin fabrication for regeneration: adapting to commercial challenges. Current Opinion in Biomedical Engineering, 10, 165-173. https://doi.org/10.1016/j.cobme.2019.07.001
Matei, A. E., Chen, C. W., Kiesewetter, L., Gyorfi, A. H., Li, Y. N., Trinh-Minh, T., Xu, X., Tran Manh, C., van Kuppevelt, T., Hansmann, J., Jüngel, A., Schett, G., Groeber-Becker, F., & Distler, J. H. W. (2019). Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Ann Rheum Dis, 78(12), 1686-1692. https://doi.org/10.1136/annrheumdis-2019-216108
Michalak-Micka, K., Klar, A. S., Bottcher-Haberzeth, S., Reichmann, E., Meuli, M., & Biedermann, T. (2019). Impact of human mesenchymal cells of different body site origins on the maturation of dermo-epidermal skin substitutes. Pediatr Surg Int, 35(1), 121-127. https://doi.org/10.1007/s00383-018-4383-5
Morel, A., Oberle, S. C., Ulrich, S., Yazgan, G., Spano, F., Ferguson, S. J., Fortunato, G., & Rossi, R. M. (2019). Revealing non-crystalline polymer superstructures within electrospun fibers through solvent-induced phase rearrangements. Nanoscale, 11(36), 16788-16800. https://doi.org/10.1039/c9nr04432a
Polomska, A. K., Proulx, S. T., Brambilla, D., Fehr, D., Bonmarin, M., Brandli, S., Meboldt, M., Steuer, C, Vasileva T., Reinke, N., Leroux, J.-C., & Detmar, M. (2019). Minimally invasive method for the point-of-care quantification of lymphatic vessel function. JCI Insight, 4(4). https://doi.org/10.1172/jci.insight.126515
Tuncer, E., Calçada, R. C., Zingg, D., Varum, S., Cheng, P., Freiberger, S. N., Deng, C.-X., Kleiter, I., Levesque, M. P., Dummer, R., & Sommer, L. (2019). SMAD signaling promotes melanoma metastasis independently of phenotype switching. J. Clin. Invest., 129:2702-2716. https://doi.org/10.1172/JCI94295
Varum, S., Baggiolini, A., Zurkirchen, L., Kalender Atak, Z., Cantù, C., Marzorati, E., Bossart, R., Wouters, J., Häusel, J., Tuncer, E., Zingg, D., Veen, D., John, N., Balz, M., Levesque, M. P., Basler, K., Aerts, S., Zamboni, N., Dummer, R. & Sommer, L. (2019). Yin Yang 1 orchestrates a metabolic program required for both neural crest development and melanoma formation. Cell Stem Cell, 24:637-653. https://doi.org/10.1016/j.stem.2019.03.011
Wahlsten, A., Pensalfini, M., Stracuzzi, A., Restivo, G., Hopf, R., & Mazza, E. (2019). On the compressibility and poroelasticity of human and murine skin. Biomech Model Mechanobiol, 18(4), 1079-1093. https://doi.org/10.1007/s10237-019-01129-1
2018
Mueller, B., Elrod, J., Pensalfini, M., Hopf, R., Distler, O., Schiestl, C., & Mazza, E. (2018). A novel ultra-light suction device for mechanical characterization of skin. PLoS One, 13(8), e0201440. https://doi.org/10.1371/journal.pone.0201440
Parfejevs, V., Debbache, J., Shakhova, O., Schaefer, S. M., Glausch, M., Wegner, M., Suter, U., Riekstina, U., Werner, S., & Sommer, L. (2018). Injury-activated glial cells promote wound healing of the adult skin in mice. Nature Communications, 9, 236. https://doi.org/10.1038/s41467-017-01488-2
Pensalfini, M., Meneghello, S., Lintas, V., Bircher, K., Ehret, A. E., & Mazza, E. (2018). The suture retention test, revisited and revised. Journal of the Mechanical Behavior of Biomedical Materials, 77, 711-717. https://doi.org/10.1016/j.jmbbm.2017.08.021
Pensalfini, M., Weickenmeier, J., Rominger, M., Santoprete, R., Distler, O., & Mazza, E. (2018). Location-specific mechanical response and morphology of facial soft tissues. Journal of the Mechanical Behavior of Biomedical Materials, 78, 108-115. https://doi.org/10.1016/j.jmbbm.2017.10.021
Randall, M. J., Jungel, A., Rimann, M., & Wuertz-Kozak, K. (2018). Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models. Front Bioeng Biotechnol, 6, 154. https://doi.org/10.3389/fbioe.2018.00154
Zimmerli, D., Cecconi, V., Valenta, T., Hausmann, G., Cantu, C., Restivo, G., Hafner, J., Basler, K., & Van den Broek, M. (2018). WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma. Oncogene, 37(27), 3753-3762. https://doi.org/10.1038/s41388-018-0244-x
Zingg D, Debbache J, Peña-Hernández R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calçada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L (2018). EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell 34: 69-84. https://doi.org/10.1016/j.ccell.2018.06.00
2017
Klar, A. S., Biedermann, T., Michalak, K., Michalczyk, T., Meuli-Simmen, C., Scherberich, A., Meuli, M., & Reichmann, E. (2017). Human Adipose Mesenchymal Cells Inhibit Melanocyte Differentiation and the Pigmentation of Human Skin via Increased Expression of TGF-beta1. J Invest Dermatol, 137(12), 2560-2569. https://doi.org/10.1016/j.jid.2017.06.027
Pensalfini, M., Ehret, A. E., Stüdeli, S., Marino, D., Kaech, A., Reichmann, E., & Mazza, E. (2017). Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering. J Mech Behav Biomed, 69, 85-97. https://doi.org/10.1016/j.jmbbm.2016.12.004
Pensalfini, M., Haertel, E., Hopf, R., Wietecha, M., Werner, S., & Mazza, E. (2017). The mechanical fingerprint of murine excisional wounds. Acta Biomater, 1-11. https://doi.org/10.1016/j.actbio.2017.10.021