Materials-skin interactions, Biomimetic materials, Smart membranes and textiles, Tissue engineering
What we investigate
Our laboratory studies materials-skin interactions and develops materials and systems to be used in the fields of medical applications, occupational safety (accident prevention), and sport. In particular, we focus on materials and systems that can help to maintain the physical integrity or to relieve pain of human skin.
Our research in more detail
Biomaterials that can promote in situ regeneration of skin tissues are desirable in many clinic scenarios. Due to the complexity of wound healing and the diversity of wound situations, an ideal dressing biomaterial for this purpose should fulfil multiple requirements. The common ones include excellent biocompatibility, tissue adhesion, anti-bacterial and controllable dehydration, etc. Other requirements include facile customization for personalized wound care. An important research line in our lab is to develop smart textiles and membranes. In particular, we are interested in smart hybrid membranes integrating electrospun nanofiber membranes with cell-compatible hydrogel adhesives to meet these requirements. This unique combination could fulfil both general requirements and patient-specific customization. With proper design and materials selection, the outer layer of nanofiber membrane could be hydrophobic and anti-bacterial, thus preventing infections and dehydration; while the inner layer could be hydrophilic to improve the adhesion with the hydrogel adhesive deposited on the wound site. More importantly, the hydrogel adhesive could be crosslinked with NIR cleavable linkers, thus enabling case-specific on-demand degradation of the hydrogel matrix. In order to generate optimized in situ skin wound healing, it can be easily personalized using patient-specific bioactive agents, such as cells and growth factors.
SKINTEGRITY.CH Principal Investigators are underlined:
- Brunelli M, Alther S, Rossi R M, Ferguson S J, Rottmar M, Fortunato G, (2020). Nanofiber membranes as biomimetic and mechanically stable surface coatings. Materials Science and Engineering: C, 108, 110417.
- Amarjargal A, Brunelli M, Fortunato G, Spano F, Kim C S, Rossi R M (2019). On-demand drug release from tailored blended electrospun nanofibers. Journal of Drug Delivery Science and Technology, 52, 8-14.
- Morel A, Oberle S, Ulrich S, Yazgan G, Spano F, Ferguson S J, Fortunato G, Rossi R M, (2019), Revealing the non-crystalline superstructures within electrospun fibers through solvent-induced phase rearrangements, Nanoscale, 11,16788–16800
- Weidenbacher L, Müller E, Guex A G, Zündel M, Schweizer P, Marina V, Adlhart C, Vejsadová L, Pauer R, Spiecker E, Maniura-Weber K, Ferguson S J, Rossi R M, Rottmar M, Fortunato G (2019). In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces. ACS applied materials & interfaces, 11(6), 5740-5751.
- Wei K+, Senturk B+, Matter M T, Wu X, Herrmann I K, Rottmar M, Toncelli C (2019). Mussel-Inspired Injectable Hydrogel Adhesive Formed under Mild Conditions Features Near-Native Tissue Properties. ACS Applied Materials & Interfaces, 11, 47707-47719.